Fan, Chi-Shuan, Chen, Chia-Chi, Chen, Li-Li, Chua, Kee Voon, Hung, Hui-Chen, Hsu, John T.-A., and Huang, Tze-Sing* (2022) Extracellular HSP90α induces MyD88-IRAK complex-associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization. Cells 11 (2): 229 (On-line publication on January 11, 2022; doi: 10.3390/cells11020229)[*Corresponding author].
Chua, Kee Voon, Fan, Chi-Shuan, Chen Li-Li, Chen Chia-Chi, Hsieh Shu-Chen, and Huang, Tze-Sing* (2020) Octyl gallate induces pancreatic ductal adenocarcinoma cell apoptosis and suppresses endothelial-mesenchymal transition-promoted M2-macrophages, HSP90α secretion, and tumor growth. Cells 9 (1): 91 (On-line first publication on December 30, 2019; doi: 10.3390/cells9010091)[*Corresponding author].
Fan, Chi-Shuan, Chen, Li-Li, Hsu, Tsu-An, Chen, Chia-Chi, Chua, Kee Voon, Li, Chung-Pin, and Huang, Tze-Sing* (2019) Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma. J. Hematol. Oncol. 12: 138 (On-line publication on December 17, 2019; doi: 10.1186/s13045-019-0826-2)[*Corresponding author].
Chen, Chia-Chi, Chen, Li-Li, Li, Chung-Pin, Hsu, Yu-Ting, Fan, Chi-Shuan, Chua, Kee Voon, Huang, Sheng-Xiang, Shyr, Yi-Ming, Chen, Li-Tzong, and Huang, Tze-Sing* (2018) Myeloid-derived macrophages and secreted HSP90α induce pancreatic ductal adenocarcinoma development. OncoImmunology 7 (5): e1424612 (On-line first publication on February 1, 2018; doi: 10.1080/2162402X.2018.1424612)[*Corresponding author].
Fan, Chi-Shuan, Chen, Wei-Shone, Chen, Li-Li, Chen, Chia-Chi, Hsu, Yu-Ting, Chua, Kee Voon, Wang, Horng-Dar, and Huang, Tze-Sing* (2018) Osteopontin–integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. Oncotarget 9 (4): 4998-5015 (On-line first publication on December 22, 2017; doi: 10.18632/oncotarget.23578)[*Corresponding author].
Yeh, Ming-Han, Chang, Ya Hui, Tsai, Yi-Chih, Chen, Su-Liang, Huang, Tze-Sing, Chiu, Jeng-Fong, and Ch’ang, Hui-Ju (2016) Bone marrow derived macrophages fuse with intestine stromal cells and contribute to chronic fibrosis after radiation. Radiother. Oncol. 119 (2): 250-258 (On-line first publication on February 15, 2016; doi: 10.1016/j.radonc.2016.01.025).
Huang, Tze-Sing, Chen, Yi-Jen, Chou, Teh-Ying, Chen, Chih-Yao, Li, Hsin-Yang, Huang, Ben-Shian, Lan, Hsin-Yi, Chang, Cheng-Hsuan, Twu, Nae-Fang, Yen, Ming-Shyen, Wang, Peng-Hui, Chao, Kuan-Chong, Lee, Chun-Chung, and Yang, Muh-Hwa (2014) Oestrogen-induced angiogenesis promotes adenomyosis by activating the Slug-VEGF axis in endometrial epithelial cells. J. Cell. Mol. Med. 18 (7): 1358-1371 (On-line first publication on April 24, 2014; doi: 10.1111/jcmm.12300).
Chen, Chia-Chi, Chen, Li-Li, Hsu, Yu-Ting, Liu, Ko-Jiunn, Fan, Chi-Shuan, and Huang, Tze-Sing* (2014) The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells. J. Biol. Chem. 289 (14): 10029-10044 (On-line first publication on February 18, 2014; doi: 10.1074/jbc.M113.528406)[*Corresponding author].
Hsiao, Kuan-Chung, Shih, Neng-Yao, Fang, Hsun-Lang, Huang, Tze-Sing, Kuo, Ching-Chuan, Chu, Pei-Yi, Hung, Yi-Mei, Chou, Shao-Wen, Yang, Yi-Yuan, Chang, Gee-Chen, and Liu, Ko-Jiunn (2013) Surface α-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target. PLOS ONE 8 (7): e69354 (On-line publication on July 19, 2013; doi: 10.1371/journal.pone.0069354).
Cheng, An-Ning, Jiang, Shih-Sheng, Fan, Chi-Chen, Lo, Yu-Kang, Kuo, Chan-Yen, Chen, Chung-Hsing, Liu, Ying-Lan, Lee, Chun-Chung, Chen, Wei-Shone, Huang, Tze-Sing, Wang, Tao-Yeuan, and Lee, Alan Yueh-Luen (2013) Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer Lett. 337 (2): 218-225 (On-line first publication on June 3, 2013; doi: 10.1016/j.canlet.2013.05.008).
Chen, Wei-Shone, Chen, Chia-Chi, Chen, Li-Li, Lee, Chun-Chung, and Huang, Tze-Sing* (2013) Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion. J. Biol. Chem. 288 (13): 9001-9010 (On-line first publication on February 5, 2013; doi: 10.1074/jbc.M112.437897) [*Corresponding author].
Lee, Chun-Chung, Chen, Wei-Shone, Chen, Chia-Chi, Chen, Li-Li, Lin, Yi-Shing, Fan, Chi-Shuan, and Huang, Tze-Sing* (2012) TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer. J. Biol. Chem. 287 (4): 2798-2809 (On-line first publication on November 30, 2011; doi: 10.1074/jbc.M111.258947)[*Corresponding author].
Chen, Wei-Shone, Lee, Chun-Chung, Hsu, Yuan-Ming, Chen, Chia-Chi, and Huang, Tze-Sing* (2011) Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis. Int. J. Colorect. Dis. 26 (8): 1009-1017 (On-line first publication on April 25, 2011; doi: 10.1007/s00384-011-1200-1)[*Corresponding author].
Liu, Ko-Jiunn, Lee, Yueh-Lun, Yang, Yi-Yuan, Shih, Neng-Yao, Ho, Chia-Chen, Wu, Yu-Chen, Huang, Tze-Sing, Huang, Ming-Chyi, Liu, Hsing-Cheng, Shen, Winston, and Leu, Sy-Jye (2011) Modulation of the development of human monocyte-derived dendritic cells by lithium chloride. J. Cell. Physiol. 226: 424-433 (On-line first publication on July 29, 2010; doi: 10.1002/jcp.22348).
Lee, Chun-Chung, Liu, Ko-Jiunn, Wu, Yu-Chen, Lin, Su-Jane, Chang, Ching-Chun, and Huang, Tze-Sing* (2011) Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells. Inflammation 34 (3): 209-221 (On-line first publication on July 9, 2010; doi: 10.1007/s10753-010-9226-z)[*Corresponding author].
Chen, Jinn-Shiun, Hsu, Yuan-Ming, Chen, Cha-Chi, Chen, Li-Li, Lee, Chun-Chung, and Huang, Tze-Sing* (2010) Secreted heat shock protein 90α induces colorectal cancer cell invasion through CD91/LRP-1 and NF-κB-mediated integrin αV expression. J. Biol. Chem. 285 (33): 25458-25466 (On-line first publication on June 17, 2010; doi: 10.1074/jbc.M110.139345)[*Corresponding author].
Tham, Sy-Jye, Chang, Ching-Dong, Huang, Hao-Jen, Lee, Yueh-Feng, Huang, Tze-Sing, and Chang, Ching-Chun (2010) Biochemical characterization of an acid phosphatase from Thermus thermophilus. Biosci. Biotechnol. Biochem. 74 (4): 727-735.
Huang, Huey-Chung, Liao, You-Di, Chen, Li-Li, and Huang, Tze-Sing* (2007) Induction of FADD expression and caspase cascades involved in RC-RNase-induced apoptosis in human cervival cancer cells. J. Cancer Mol. 3: 81-89 [*Corresponding author].
Lee, Chun-Chung, Liu, Ko-Jiunn, and Huang, Tze-Sing* (2006) Tumor-associated macrophage: its role in tumor angiogenesis. J. Cancer Mol. 2: 135-140 [*Corresponding author].
Lee, Chun-Chung, Liu, Ko-Jiunn, Chen, Li-Li, Wu, Yu-Chen, and Huang, Tze-Sing* (2006) Tumor necrosis factor-α, interleukin-8 and interleukin-6 are involved in vascular endothelial cell capillary tube and network formation induced by tumor-associated macrophages. J. Cancer Mol. 2: 155-160 [*Corresponding author].
Tsai, Shiow-Chwen, Liu, Ya-Chen, Li, Chung-Pin, Huang, Tze-Sing, and Lee, Chun-Chung (2006) Sesamin inhibits vascular endothelial cell growth and angiogenic activity of lung adenocarcinoma cells. J. Cancer Mol. 2: 199-205.
Chen, Wei-Shone, Chang, Hong-Yi, Chang, Jui-Ting, Liu, Jacqueline Ming, Li, Chung-Pin, Chen, Li-Li, Chang, Huei-Ling, Chen, Chia-Chi, and Huang, Tze-Sing* (2005) Novel rapid tissue lysis method to evaluate cancer proteins: correlation between elevated Bcl-XL expression and colorectal cancer cell proliferation. World J. Gastroenterol. 11: 5162-5168 [*Corresponding author].
Lee, Chun-Chung and Huang, Tze-Sing* (2005) Plasminogen activator inhibitor-1: the expression, biological function, and effects on tumorigenesis and tumor cell adhesion and migration. J. Cancer Mol. 1: 25-36 [*Corresponding author].
Chen, Jinn-Shiun, Chen, Wei-Shone, Liu, Jacqueline M., Chang, Jui-Ting, and Huang, Tze-Sing* (2005) Prognostic significance of elevated cyclin B1 expression in colorectal cancer: a rapid tissue lysis and immunoblot study. J. Cancer Mol. 1: 47-51 [*Corresponding author].
Chen, Wei-Shone, Chang, Hong-Yi, Li, Chung-Pin, Liu, Jacqueline Ming, and Huang, Tze-Sing* (2005) Tumor β-1,4-galactosyltransferase-IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis. Clin. Cancer Res. 11: 8615-8622 [*Corresponding author].
Li, Chung-Pin, Huang, Jen-Hsin, Chang, Ai-Chi, Hung, Yi-Mei, Lin, Chao-Hsiung, Chao, Yee, Lee, Shou-Dong, Whang-Peng, Jacqueline, and Huang, Tze-Sing* (2004) A G-quadruplex ligand 3,3’-diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells. Pharm. Res. 21: 93-100 [*Corresponding author].
Li, Chung-Pin, Huang, Tze-Sing, Chao, Yee, Chang, Full-Young, Whang-Peng, Jacquline, and Lee, Shou-Dong (2004) Advantages of assaying telomerase activity in ascites for the diagnosis of digestive tract malignancies. World J. Gastroenterol. 10: 2468-2471.
Wu, Chew-Wun, Chi, Chin-Wen, and Huang, Tze-Sing* (2004) Elevated level of spindle checkprotein MAD2 correlates with mitotic arrest of gastric cancer tissues but not aneuploidy and other clinicopathological characteristics. World J. Gastroenterol. 10: 3240-3244 [*Corresponding author].
Yuan, Chiou-Chung, Wang, Peng-Huey, Ng, Heung-Tat, Li, Y.-F., Huang, Tze-Sing, Chen, C.-Y., Tsai, Lai-Chen, and Shyong, Wen-Yuan (2002) Detecting cytokeratin 19 mRNA in the peripheral blood cells of cervical cancer patients and its clinical-pathological correlation. Gynecol. Oncol. 85: 148-153.
Huang, Tze-Sing*, Shu, Chih-Hung, Chao, Yee, and Chen, Li-Tzong (2001) Evaluation of GL331 in combination with paclitaxel: GL331’s interference with paclitaxel-induced cell cycle perturbation and apoptosis. Anti-Cancer Drug 12: 259-266 [*Corresponding author].
Lee, Chun-Chung and Huang, Tze-Sing* (2001) A novel topoisomerase II poison GL331 preferentially induces DNA cleavage on (C/G)T sites and can cause telomere DNA damage. Pharm. Res. 18: 846-851 [*Corresponding author].
Lin, Shankung, Huang, Huey-Chung, Chen, Li-Li, Lee, Chun-Chung, and Huang, Tze-Sing* (2001) GL331 induces down-regulation of cyclin D1 expression via enhanced proteolysis and repressed transcription. Mol. Pharmacol. 60: 768-775 [*Corresponding author].
Huang, Tze-Sing*, Shu, Chih-Hung, Lee, Chun-Chung, Chen, Li-Tzong, and Whang-Peng, Jacqueline (2000) In vitro evaluation of GL331’s cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents. Apoptosis 5: 79-85 [*Corresponding author].
Huang, Tze-Sing*, Shu, Chih-Hung, Chao, Yee, Chen, San-Na, and Chen, Li-Li (2000) Activation of MAD 2 checkprotein and persistence of cyclin B1/CDC 2 activity associate with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells. Apoptosis 5: 235-241 [*Corresponding author].
Huang, Tze-Sing*, Lee, Chun-Chung, Chao, Yee, Shu, Chih-Hung, Chen, Li-Tzong, Chen, Li-Li, Chen, Min-Hsiung, Yuan, Chiou-Chung, and Whang-Peng, Jacqueline (1999) A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells. Pharm. Res. 16: 997-1002 [*Corresponding author].
Chao, Yee, Shih, Yung-Luen, Chen, Hsin-Ju, Lee, Shou-Dong, and Huang, Tze-Sing* (1999) Inhibition of DNA synthesis by down regulation of cyclin A but not Skp 2 overexpression in human hepatocellular carcinoma cells. Cancer Lett. 139: 1-6 [*Corresponding author].
Chen, Min-Hsiung, Lee, Chun-Chung, Chin, Chiu-Hua, Whang-Peng, Jacquline, and Huang, Tze-Sing* (1999) Analysis of astrocytoma heterogeneity: Detection of Telomere Shortening, Bcl-2 expression, and multiple gains and losses of genetic material in four primary cultures of astrocytoma. J. Genet. Mol. Biol. 10: 102-109 [*Corresponding author].
Shen, Shing-Chuan, Huang, Tze-Sing, Jee, Shiou-Hwa, and Kuo, Min-Liang (1998) Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells. Cell Growth Differ. 9: 23-30.
Chao, Yee, Shih, Yung-Luen, Chiu, Jen-Hwey, Chau, Gar-Yang, Lui, Wing-Yu, Yang, W.K., Lee, Shou-Dong, and Huang, Tze-Sing* (1998) Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma. Cancer Res. 58: 985-990 [*Corresponding author].
Yuan, Chiou-Chung, Huang, Tze-Sing, Ng, Heung-Tat, Liu, Ren-Shyan, Hung, Mei-Whey, and Tsai, Lai-Chen (1998) Elevated cytokeratin-19 expression associated with the apoptotic resistance and malignant progression of human cervical carcinoma. Apoptosis 3: 161-169.
Chen, Min-Hsiung, Yang, Wen K., Whang-Peng, Jacqueline, Lee, Liang-Shong, and Huang, Tze-Sing* (1998) Differential inducibilities of GFAP expression, cytostasis and apoptosis in primary cultures of human astrocytic tumors. Apoptosis 3: 171-182 [*Corresponding author].
Kuo, Min-Liang, Shen, Shing-Chuan, Yang, Chih-Hsin, Chuang, Shuang-En, Cheng, Ann-Lii, and Huang, Tze-Sing (1998) Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity. Oncogene 17: 2225-2234.
Yuan, Chiou-Chung, Huang, Huey-Chung, Tsai, Lai-Chen, Ng, Heung-Tat, and Huang, Tze-Sing* (1997) Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells. Apoptosis 2: 101-105 [*Corresponding author].
Kuo, Min-Liang, Chou, Yi-Wen, Chau, Yat-Peng, and Huang, Tze-Sing (1997) Resistance to apoptosis induced by alkylating agents in v-H-ras-transformed cells due to defect in p53 function. Mol. Carcinog. 18: 221-231.
Whang-Peng, Jacqueline and Huang, Tze-Sing (1997) New trials of GL331, a novel topoisomerase II inhibitor, in treatment of solid tumors. J. Intern. Med. 8: 6-11.
Huang, Tze-Sing*, Shu, Chih-Hung, Yang, Wen K., and Whang-Peng, Jacqueline (1997) Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis. Cancer Res. 57: 2974-2978 [*Corresponding author].
Shu, Chih-Hung, Yang, Wen K., Shih, Yung-Luen, Kuo, Min-Liang, and Huang, Tze-Sing* (1997) Cell cycle G2/M arrest and activation of cyclin-dependent kinases associated with low-dose paclitaxel-induced sub-G1 apoptosis. Apoptosis 2: 463-470 [*Corresponding author].
Huang, Tze-Sing, Kuo, Min-Liang, Shew, Jin-Yuh, Chou, Yi-Wen, and Yang, Wen K. (1996) Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA damaging agents. Oncogene 13: 625-632.
Kuo, Min-Liang, Huang, Tze-Sing, and Lin, Jen-Kun (1996) Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim. Biophys. Acta 1317: 95-100.
Shu, Chih-Hung, Yang, Wen K., and Huang, Tze-Sing* (1996) Increased cyclin B1-associated CDC 2 kinase activity and phosphorylation of Bcl-2 associated with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells. Apoptosis 1: 141-146 [*Corresponding author].
Huang, Tze-Sing*, Shu, Chih-Hung, Shih, Yung-Luen, Huang, Huey-Chung, Su, Yi-Chun, Chao, Yee, Yang, Wen K., and Whang-Peng, Jacqueline (1996) Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide. Cancer Lett. 110: 77-85 [*Corresponding author].
Huang, Tze-Sing*, Yang, Wen K., and Whang-Peng, Jacqueline (1996) GL331-induced disruption of cyclin B1/CDC 2 complex and inhibition of CDC 2 kinase activity. Apoptosis 1: 213-217 [*Corresponding author].
Huang, Tze-Sing, Duyster, Justus, and Wang, Jean Y.J. (1995) Biological response to phorbol ester determined by alternative G1 pathways. Proc. Natl. Acad. Sci. USA. 92: 4793-4797.
Kuo, Min-Liang, Lee, Kwen-Chen, Lin, Jen-Kun, and Huang, Tze-Sing (1995) Pronounced activation of protein kinase C, ornithine decarboxylase and c-jun proto-oncogene by paraquat-generated active oxygen species in WI-38 human lung cells. Biochim. Biophys. Acta 1268: 229-236.
Huang, Tze-Sing*, Kuo, Min-Liang, Lin, Jen-Kun, and Hsieh, Jingle S. C. (1995) A labile hyperphosphorylated c-Fos protein is induced in mouse fibroblast cells treated with a combination of phorbol ester and anti-tumor promotor curcumin. Cancer Lett. 96: 1-7 [*Corresponding author].
Kuo, Min-Liang, Huang, Tze-Sing, and Lin, Jen-Kun (1995) Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human colon cancer cells. Biochem. Pharmacol. 50: 1217-1222.
Chen, Min-Chun, Huang, Tze-Sing, Chen, Min-Hsiung, and Wang, Chuan-Cheng (1995) Cathepsin D and breast cancer’s connection: Fifteen years later. J. Chin. Oncol. Soc. 11: 16-30.
Lin, Jen-Kun, Huang, Tze-Sing, Shih, Cheng-An and Liu, Jer-Yuh (1994) Molecular mechanism of action of curcumin: Inhibition of 12-O-tetradecanoylphorbol-13-actate-induced responses associated with tumor promotion. Am. Chem. Soc. Sym. Ser. 547: 196-203.
Kuo, Min-Liang, Lin, Jen-Kun, Huang, Tze-Sing, and Yang, Nae-Cherng (1994) Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett. 87: 91-97.
Huang, Tze-Sing, Lee, Sheng-Chung, and Lin, Jen-Kun (1991) Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA. 88: 5292-5296.
Lin, Jen-Kun, Huang, Tze-Sing, Hsue, Bi-Lan, and Luh, Kwen-Tay (1990) An improved procedure for isolation of large R plasmid DNA from Escherichia coli NTUH 9501-1. J. Genet. Mol. Biol. 1: 7-13.
Lin, Jen-Kun, Huang, Tze-Sing, and Luh, Kwen-Tay (1989) Penicillinase-type of β-lactamase responsible for the ampicillin resistance in Escherichia coli NTUH 9501-1. J. Formosan Med. Assoc. 88: 1-7.
