夏興國 副研究員－論文

PUBLICATIONS  (*Corresponding authors):
  1. Chou ST, Peng HY, Mo KC, Hsu YM, Wu GH, Hsiao JR, Lin SF, Wang HD, Shiah SG*. MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1. J Exp Clin Cancer Res. 2019 Jun 28, 38(1):281.
  2. Hsing EW, Shiah SG, Peng HY, Chen YW, Chuu CP, Hsiao JR, Lyu PC, Chang JY. TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility. PLoS One. 2019 Mar, 14(3):e0213463.
  3. Chiang CF, Chao TT, Su YF, Hsu CC, Chien CY, Chiu KC, Shiah SG, Lee CH, Liu SY, Shieh YS. Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling. Oncotarget. 2017 Mar. Oncotarget. 2017 Mar 28, 8(13):20706-20718.
  4. Chang WM, Lin YF*, Su CY, Peng HY, Chang YC, Hsiao JR, Chen CL, Chang JY, Shieh YS, Hsiao M, Shiah SG*. Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation. Sci Rep. 2017 Jan, 7:41131.
  5. Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS*, Hsiao M*, Shiah SG*. Dysregulation of Runx2/Activin A axis upon miR376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinoma. Cancer Res. 2016 Dec 15, 76(24):1-11.
  6. Peng HY, Cheng YC, Hsu YM, Wu GH, Kuo CC, Liou JP, Chang JY, Jin SL*, Shiah SG*. MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma. PLoS One. 2016 Jul, 11(7):e0158440.
  7. Cheng CM, Shiah SG, Huang CC, Hsiao JR, and Chang JY. Up-regulation of miR-455-5p by the TGF-β-SMAD signaling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B. J. Pathol. 2016 Sep, 240(1): 38-49.
  8. Peng HY, Jiang SS, Hsiao JR, Hsiao M, Hsu YM, Wu GH, Chang WM, Chang JY, Jin CSL*, Shiah SG*. IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma. Molecular Oncology. 2016 Jun, 106(6): 895-909.
  9. Cho CY, Huang JS, Shiah SG, Chung SY, Lay JD, Yang YY, Lai GM, Cheng AL, Chen LT, Chuang SE. Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells. RNA. 2016 Feb, 22(2): 303-15.
  10. Shiah SG, Shieh YS, Chang JY. The Role of Wnt Signaling in Squamous Cell Carcinoma. J. Dent. Res. 2016 Feb, 95(2): 129-34.
  11. Wen HC, Chuu CP, Chen CY, Shiah SG, Kung HJ, King KL, Su LC, Chang SC, Chang CH. Elevation of soluble guanylate cyclase suppresses proliferation and survival of human breast cancer cells. PLoS One. 2015 Apr 30, 10(4):e0125518.
  12. Shiah SG#, Hsiao JR#, Chang WM, Chen YW, Jin YT, Wong TY, Huang JS, Tsai ST, Hsu YM, Chou ST, Yen YC, Jiang SS, Shieh YS, Chang IS, Hsiao M, Chang JY. Downregulated miRNA-329 and miRNA-410 promote tumor proliferation and invasion through the Wnt/β-catenin signaling pathway by targeting Wnt-7b in oral squamous cell carcinoma. Cancer Res. 2014 Dec 15, 74(24):7560-72.(#Co-first authors)
  13. Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH, Hung MC, Hsu NW, Shiah SG, Hsu NY, Su JL. Dicer-mediated miR-326 maturation is crucial for VEGF-C-induced cortactin expression and esophageal cancer progression. Cancer Res. 2014 Nov; 74(21):6280-90.
  14. Lee CH, Liu SY, Chou KC, Yeh CT, Shiah SG, Huang RY, Cheng JC, Yen CY, Shieh YS. Tumor-associated macrophages promote oral cancer progression through activation of the Axl signaling pathway. Ann Surg Oncol. 2014 Mar; 21(3):1031-7.
  15. Yen YC#, Shiah SG#, Chu HC, Hsu YM, Hsiao JR, Chang JY, Hung WC, Liao CT, Cheng AJ, Lu YC, Chen YW. Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol Cancer. 2014 Jan; 13:6. (#Co-first authors)
  16. Tu YC, Huang DY, Shiah SG, Wang JS, Lin WW. Regulation of c-Fos Gene Expression by NF-kB: A p65 Homodimer Binding Site in Mouse Embryonic Fibroblasts but Not Human HEK293 Cells. PLoS One. 2013 Dec; 8(12): e84062.
  17. Wu CA, Chao Y, Shiah SG, Lin WW. Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase. BBA-Mol. Cell Res., 2013 May; 1833(5):1147-56.
  18. Sher YP, Chang CM, Juo CG, Chen CT, Hsu JL, Lin CY, Han Z, Shiah SG, Hung MC. Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth. Oncogene. 2013 Feb; 32(9):1082-1090.
  19. Lee CH, Yen CY, Liu SY, Chen CK, Chiang CF, Shiah SG, Chen PH, Shieh YS. Axl Is a Prognostic Marker in Oral Squamous Cell Carcinoma. Ann Surg Oncol., 2012 Jul; 19(Suppl 3):500-508.
  20. Chiu LY, Ho FM, Shiah SG, Chang Y, Lin WW. Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death. Biochem Pharmacol., 2011, 81(3):459-70.
  21. Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res., 2010, 70(20):7830-40.
  22. Shiah SG, Chang LC, Tai KY, Lee GH, Wu CW, Shieh YS. The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma. Oral Oncology, 2009, 45(1):e1-8.
  23. Tai KY, Shieh YS, Lee CS, Shiah SG*, Wu CW*. Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1. Oncogene, 2008, 27(29):4044-55.
  24. Shiah SG, Tai KY. Wu CW. Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis. J. Cancer Mol. 2008, 3(6):165-168. (invited review)
  25. Tai KY.#, Shiah SG#, Shieh YS, Kao YR, Chi CY, Wu CW. DNA methylation and histone modification regulate silencing of Ep-CAM for tumor invasion and progression. Oncogene. 2007, 26(27):3989-97. (#Co-first authors)
  26. Shieh YS, Lai CY, Kao YR, Shiah SG, Chu YW, Wu CW. Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia. 2005, 7(12):1058-64.
  27. ShiehYS, Shiah SG, Jeng HH, Lee HS, Wu CW, Chang LC. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Cancer. 2005,104(5):1013-21。
  28. Su JL, Lin MT, Hong CC, Chang CC, Shiah SG, Wu CW, Chen ST, Chau YP, Kuo ML. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK- dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis. 2005, 26(1):1-10.
  29. Shieh YS, Lee HS, Shiah SG, Chu YW, Wu CW, Chang LC. Role of angiogenetic and non-angiogenic mechanisms in oral squamous cell carcinoma: correlation with histologic differentiation and tumor progression. J. Oral Pathol. Med., 2004, 33(10):601-6.
  30. Shiah SG, Kao YR., Wu FYH. Wu CW. Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram. Mol. Pharmacol., 2003, 64(5):1-9.
  31. Tsai PW, Shiah SG, Lin MT, Wu CW, Kuo ML. Up-regulation of Vascular Endothelial Growth Factor C in Breast Cancer Cells by Heregulin-1. J. Biol. Chem. 2003, 278(8): 5750-5759.
  32. Shiah SG, Chuang SE, Kuo ML. Involvement of Asp-Glu-Val-Asp-Directed, Caspase-Mediated Mitogen –Activated Protein Kinase Kinase 1 Cleavage, c-Jun N-Terminal Kinase Activation, and Subsequent Bcl-2 Phosphorylation for Paclitaxel-Induced Apoptosis in HL-60 Cells. Mol. Pharmacol., 2001, 59(2):254-262.
  33. Chang ST, Wang DS, Wu CL, Shiah SG, Kuo YH, Chang CJ. Cytotoxicity of extractives from Taiwania cryptomerioides heartwood. Phytochemistry, 2000, 55(3):227-232.
  34. Ho FM, Liu SH, Liau CS, Huang PJ, Shiah SG, Lin-Shiau SY. Nitric oxide prevents apoptosis of human endothelial cells from high glucose exposure during early stage. J Cell. Biochem., 1999, 75(2):258-263.
  35. Kuo ML, Shiah SG, Wang CJ, Chuang SE. Suppression of apoptosis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis. Mol. Pharmacol., 1999, 55(5):894-901.
  36. Shiah SG, Chuang SE, Chau YP, Shen SC, Kuo ML. Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation- dependent pathway. Cancer Res., 1999, 59(2):391-398.
  37. Chau YP, Shiah SG, Don MJ, Kuo ML. Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone- induced apoptosis and differentiation in human leukemia cells. Free Radical Bio. Med., 1998, 24(4):660-670.
  38. Kuo ML, Chau YP, Wang JH, Shiah SG. Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. Biochem. Bioph. Res. Co., 1996, 219(2):502-508.
  39. Yang SD, Yu JS, Shiah SG, Huang JJ. Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorrylated in Alzheimer’s disease brain. J Neurochem., 1994, 63(4):1416-1425.
  40. Yang SD, Song JS, Yu JS, Shiah SG. Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer’s disease brain. J Neurochem., 1993, 61(5):1742-1747.

Conference abstract (Since 2012):

  1. Wu GH, Mo KC, Hsiao M, Shieh YS, Chuang SE, Shiah SG#. Axl-mediated Epigenetic Repression of MiR-483-5p Upregulates Elk-1 and Promotes Proliferation of Breast Cancer Cells. The 77th Annual Meeting of the Japanese Cancer Association. Kyoto, Japan, Sep 26-28, 2019.
  2. Shiah SG#. Chou ST, Kuo CC, Chi YH. A Novel Mechanism of miRNA-Mediated CBX8 Associated with Tumorigenesis in Head and Neck Squamous Cell Carcinoma. The 2019 Annual Meeting of ASCO. Chicago, USA, May 31-June 4, 2019.
  3. Chou ST, Hsiao JR, Ling SF, Wang HD, Fang CY, Chen TT, Shiah SG#. MicroRNA-486-3p Functions as a Tumor Suppressor in Oral Cancer by Targeting DDR1. The 34th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 23-24, 2019.
  4. Wu GH, Mo KC, Hsiao M, Shieh YS, Chuang SE, Shiah SG#. Axl-mediated Epigenetic Repression of Mir-483-5p Upregulates Elk-1 and Promotes Proliferation of Breast Cancer Cells. The 34th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 23-24, 2019.
  5. Peng HY, Hsiao JR, Hsu YM, Wu GH, Chou ST, Chang WM, Shieh YS, Shiah SG#. NNK induces miR-944 expression and modulates CISH/STAT3 signaling pathway in oral squamous cell carcinoma. The 77th Annual Meeting of the Japanese Cancer Association. Osaka, Japan, Sep 27-29, 2018.
  6. Chou ST, Hsiao JR, Chang JY, Wang HD#, and Shiah SG#. A novel mechanism of miRNA-mediated CBX8 associated with tumorigenesis in head and neck cancer. 2016 NHRI-NTHU Joint Research Conference, Miaoli, Taiwan, Nov 21. 2016.
  7. Chang HJ, Hsiao JR, Li WS, Chang JY, and Shiah SG#. MicroRNA-dependent regulation of DNA methyltransferase-3b in the retinoid acid metabolic genes during oral carcinogenesis. ISREC-SCCL Symposium 2016: Horizons of Cancer Biology and Therapy, Lausanne, Swiss, Sep 7-10, 2016.
  8. Wu GH, Mo KC, Hsiao M, Shieh YS, Chuang SE and Shiah SG#. Axl-mediated Epigenetic Repression of Mir-483-5p Upregulates Elk-1 and Promotes Proliferatoion of Breast Cancer Cells. The 31th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 26-27, 2016.
  9. Chou ST, Lin SF, Wang HD, and Shiah SG#. MiR-486-3p downregulation contributes to tumor growth and survival of oral cancer by targeting DDR1. NHRI-NTHU Joint Research Conference, Miaoli, Taiwan, Dec 30. 2015.
  10. Peng HU, Hsiao JR, Hsiao M, Chang JY, Jin CSL#, Shiah SG#. MiR-424-5p is Frequently Upregulated in Oral Cancer and Modulates STAT5 Signaling Pathway by Negatively Regulating SOCS2. EACR-AACR-SIC special conference. Florence, Italy, Jun 20-23, 2015.
  11. Peng HU, Hsiao JR, Hsiao M, Chang JY, Jin CSL#, Shiah SG#. IL-8 Induces miR-424 Expression and Modulates SOCS2/STAT5 Signaling Pathway in Oral Cancer. NHRI-NCU Joint Research Conference, Miaoli, Taiwan, Apr 20. 2015.
  12. Hsing EW, Shiah SG, Hsiao JR, Lyu PC, Chang JY. The role of miR-450a in oral squamous cell carcinoma carcinogenesis. American Society for Investigative Pathology (ASIP) Annual Meeting, Boston, MA, Mar 27-Apr 1, 2015.
  13. Chang WM, Chang YU, Su CY, Lai TC, Shieh YS, Shiah SG#, Hsiao M#. MiR-376c Inhibits Metastasis by Controlling RUNX2-INHBA Axis in Oral Squamous Cell Carcinoma. American Society for Investigative Pathology (ASIP) Annual Meeting, Boston, MA, Mar 27-Apr 1, 2015.
  14. Peng HU, Hsiao JR, Hsiao M, Chang JY, Jin CSL#, Shiah SG#. Mir-30a-5p mediated progression of oral cancer and establish a functional link between mir-30a-5p and SOCS1. The 30th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 21-22, 2015.
  15. Chang WM, Chang YU, Su CY, Lai TC, Shieh YS, Shiah SG#, Hsiao M#. MiR-376c regulates Oral Squamous Carcinoma Cells Metastasis through RUNX2-INHBA Axis The 23th symposium on recently advances in cellular and molecular biology, Pingdong, Taiwan, Feb 4-6, 2015.
  16. Chang HJ, Hsu YM, Chou ST, Chang WM, Shieh YS, Hsiao M, Hsiao JR, Chang JY, Shiah SG#. MiRNA-dependent regulation of DNA methyltransferase-3b in the retinoid acid metabolic genes during oral carcinogenesis. The 73th Annual Meeting of the Japanese Cancer Association. Yokohama, Japan, Sep 24-28, 2014.
  17. Chang WM*, Chou ST, Hsu YM, Shieh YS, Hisao M, Hsiao JR#, Chang JY#, Shiah SG#. Identification of oral carcinoma miRNA signature and control OSCC tumorigenesis through Wnt/β-catenin signaling. American Association for Cancer Research (AACR) Annual Meeting 2014. San Diego, CA, Apr 5-9, 2014.
  18. Chou ST, Hsiao JR, Chang JY, Wang HD#, Shiah SG#. CBX8 Enhances Tumorigenesis and is Regulated by miR-410 in Oral Cancer. The 28th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 15-16, 2014.
  19. Peng HU, Hsiao JR, Hsiao M, Chang JY, Jin CSL#, Shiah SG#. miR-424-5p is Frequently Upregulated in Oral Cancer and Modulates STAT5 Signaling Pathway by Negatively Regulating SOCS2. The 28th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 15-16, 2014.
  20. Chang HJ, Hsu YM, Chou ST, Chang WM, Shieh YS, Hsiao M, Hsiao JR, Chang JY, Shiah SG#. MicroRNA-dependent regulation of DNA methyltransferase-3b in the retinoid acid metabolic genes during oral carcinogenesis. The 22th symposium on recently advances in cellular and molecular biology, Pingdong, Taiwan, Jan 22-24, 2014.
  21. Wu GH, Mo KC, Hsiao M, Shieh YS, Chuang SE, Shiah SG#. Axl induces MMPs expression and promotes invasiveness of lung cancer cells through downregulation of miR-1237 and miR-663b. The 22th symposium on recently advances in cellular and molecular biology, Pingdong, Taiwan, Jan 22-24, 2014.
  22. Pen HY, Chang JY#, Jin SL#, Shiah SG#. The Novel Tubulin Inhibitor, MPT0B098, Inhibits Stat3 Pathway and Induces Apoptosis via Up-regulation of SOCS3 in Oral Cancer Cells. The 28th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 23-24, 2013.
  23. Chang WM, Chou ST, Shieh YS, Hsiao JR, Chang JY#, Shiah SG#. Genome-wide Profiling Identified a Chromosome 14q32.2 miRNA Cluster that are Differentially Expressed in Oral Squamous Cell Carcinoma and Regulates Wnt/ß-catenin Signaling Pathway. The 28th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, Mar 23-24, 2013.
  24. Yen YC, #, Shiah SG#, Chu HC, Hsu YM, Hsiao JR, Chang JY, Liao CT, Cheng AJ, Lu YC, Chen YW. MicroRNA-99a, a Tumor Suppressor in Oral Squamous Cell Carcinoma Regulates Insulin-like Growth Factors I Receptor in a Double-Negative Feedback Loop. 24th EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”, Dublin, Ireland, Nov. 4-8, 2012.
  25. Shiah SG#, Chang JY. MicroRNA signature and exploration in human oral squamous cell carcinomas. 3rd International Conference on Biomarkers & Clinical Research, Las Vegas, USA, July, 2-4, 2012.

Invited Speech:

  1. Invited speaker, “microRNA-mediated epigenetic regulation in oral cancer: from bench to bedside.” Organized by Department of Life Sciences, Tzu Chi University, Hualien, Taiwan (2016).
  2. Invited speaker, “The effect of nutrient on miRNA regulation.” In “2015 Cancer and Nutrition Symposium” organized by The Chinese Oncology Society & Taiwan Society for Parenteral and Enteral Nutrition. Taipei, Taiwan (2015).
  3. Invited speaker, “The roles of microRNA in cancer metastasis.” Organized by Department of Life Sciences, National Central University, Taoyuan, Taiwan (2011)
  4. Invited speaker, “The current development and applications of experimental animal study.” Organized by Department of Animal Science, Chinese Culture University, Taipei, Taiwan (2011).
  5. Invited speaker, “DNA methylation and histone modification of epithelial cell adhesion molecule in lung cancer.” In The 23rd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan (2008).
  6. Invited speaker, “Molecular-target therapy and diagnosis in cancer.” In “2008醫檢新知研討會-癌症預防醫療檢驗現況與發展”, 新竹, 台灣 (2008).
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